ProGP177 (HRgpA)

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ProGP ID ProGP177 (HRgpA)
Validation Status Uncharacterized
Organism Information
Organism NamePorphyromonas gingivalis W50
Domain Bacteria
Classification Phylum : Bacteroidetes
Class : Bacteroidia
Orders : Bacteroidales
Family : Porphyromonadaceae
Genus : Porphyromonas
Species : gingivalis
Strain : W50
Taxonomic ID (NCBI) 837
Genome Information
GenBank AF017059
EMBL AF017059
Organism Additional Information Porphyromonas gingivalis is a Gram-negative anaerobic bacterium responsible for causing adult periodontal disease, a chronic inflammatory condition of the periodontal tissues. It is the source of a number of virulence factors that are thought to be important for deregulation of innate and inflammatory systems in the host.
Protein Information
Protein NameHRgpA
Subcellular LocationExtracellular
Function Cysteine proteases cause the degradation of several physiologically important proteins, including collagens, fibrin and fibrinogen and fibronectin. They also account for deregulatory effects on several host systems and are therefore considered important virulence determinants. The adhesin domains of Arg-gingipains mediate the adherence of P. gingivalis to epithelial cells.
Glycosylation Status
Technique(s) used for Glycosylation DetectionCarbohydrate determination by methanolysis and GC-MS after beta-elimination.
Glycan Information
Glycan Annotation Rha, Man, Gal, Glc, GalN(Ac), and GlcN(Ac) (i.e.,lacking Ara, Fuc, and NANA) totalling 2.1% by weight of protein.
Year of Identification1999
Year of Identification Month Wise1999.8
ReferenceCurtis, M.A., Thickett, A., Slaney, J.M., Rangarajan, M., Aduse-Opoku, J., Shepherd, P., Paramonov, N. and Hounsell, E.F., 1999. Variable carbohydrate modifications to the catalytic chains of the RgpA and RgpB proteases of Porphyromonas gingivalis W50. Infection and immunity, 67(8), pp.3816-3823.
Corresponding Author Michael A. Curtis
ContactMRC Molecular Pathogenesis Group, Department of Oral Microbiology, St. Bartholomew's and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, London E1 2AA, United Kingdom.