ProGP177 (HRgpA)
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| ProGP ID | ProGP177 (HRgpA) |
| Validation Status | Uncharacterized |
| Organism Information | |
| Organism Name | Porphyromonas gingivalis W50 |
| Domain | Bacteria |
| Classification | Phylum : Bacteroidetes Class : Bacteroidia Orders : Bacteroidales Family : Porphyromonadaceae Genus : Porphyromonas Species : gingivalis Strain : W50 |
| Taxonomic ID (NCBI) | 837 |
| Genome Information | |
| GenBank | AF017059 |
| EMBL | AF017059 |
| Organism Additional Information | Porphyromonas gingivalis is a Gram-negative anaerobic bacterium responsible for causing adult periodontal disease, a chronic inflammatory condition of the periodontal tissues. It is the source of a number of virulence factors that are thought to be important for deregulation of innate and inflammatory systems in the host. |
| Protein Information | |
| Protein Name | HRgpA |
| Subcellular Location | Extracellular |
| Function | Cysteine proteases cause the degradation of several physiologically important proteins, including collagens, fibrin and fibrinogen and fibronectin. They also account for deregulatory effects on several host systems and are therefore considered important virulence determinants. The adhesin domains of Arg-gingipains mediate the adherence of P. gingivalis to epithelial cells. |
| Glycosylation Status | |
| Technique(s) used for Glycosylation Detection | Carbohydrate determination by methanolysis and GC-MS after beta-elimination. |
| Glycan Information | |
| Glycan Annotation | Rha, Man, Gal, Glc, GalN(Ac), and GlcN(Ac) (i.e.,lacking Ara, Fuc, and NANA) totalling 2.1% by weight of protein. |
| Literature | |
| Year of Identification | 1999 |
| Year of Identification Month Wise | 1999.8 |
| Reference | Curtis, M.A., Thickett, A., Slaney, J.M., Rangarajan, M., Aduse-Opoku, J., Shepherd, P., Paramonov, N. and Hounsell, E.F., 1999. Variable carbohydrate modifications to the catalytic chains of the RgpA and RgpB proteases of Porphyromonas gingivalis W50. Infection and immunity, 67(8), pp.3816-3823. |
| Corresponding Author | Michael A. Curtis |
| Contact | MRC Molecular Pathogenesis Group, Department of Oral Microbiology, St. Bartholomew's and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, London E1 2AA, United Kingdom. |