Escherichia coli (Gram-negative) is the predominant facultative organism in the human intestine. It is responsible for a number of diseases like urinary tract infections, gastroenteritis (diarrhoea), meningitis, traveler's diarrhea and hemorrhagic colitis. There are a myriad of serotypes of pathogenic E. coli. Adhesion to the host cells is an important step in its pathogenesis. However, most strains are harmless and normal flora residing in the gut.
Self-associating autotransporters (SAAT). Adhesin involved in diffuse adherence. Able to confer a pattern of diffuse adherence on the surface of cultured epithelial cells.
Glycosylation Status
Glycosylation Type
O- (Ser) linked
Experimentally Validated Glycosite(s) in Full Length Protein
AIDA- I is primarily associated with pathogenic E. coli strains involved in neonatal and postweaning diarrhea in piglets. The glycosylated peptides were identified in a region of the protein composed of imperfect 19-amino-acid repeats. Glycosylation by heptoses represents a novel protein modification in eubacteria. Sequon features: The N-terminal repeats of AIDA-I that contain multiple copies of the consensus sequence VXNSGG, might serve as acceptor sites for the AAH heptosyltransferase. UniProtKB information is provided according to Ref. no. 1 in which glycosites have been confirmed.
Canada Research Chair on Bacterial Animal Diseases, University of Montreal, Faculty of Veterinary Medicine, St.-Hyacinthe, 3200 Sicotte, St.-Hyacinthe, Quebec J2S 7C6, Canada
