ProGP24 (Flagellin FlaB3)

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ProGP ID ProGP24 (Flagellin FlaB3)
Validation Status Uncharacterized
Organism Information
Organism NameTreponema pallidum subsp. pallidum Nichols
Domain Bacteria
Classification Phylum : Spirochaetes
Class : Spirochaetia
Orders : Spirochaetales
Family : Trepnemataceae
Genus : Treponema
Species : pallidum
Subspecies : pallidum
Taxonomic ID (NCBI) 160
Genome Information
GenBank AE000520.1
EMBL AE000520
Gene Information
Gene NameflaB3 (TP_0870)
NCBI Gene ID 2611107
GenBank Gene Sequence NC_000919.1
Protein Information
Protein NameFlagellin FlaB3
UniProtKB/SwissProt ID P21992
NCBI RefSeq WP_010882313.1
EMBL-CDSAAC65835.1
UniProtKB Sequence >sp|P21992|FLAB3_TREPA Flagellar filament 31 kDa core protein OS=Treponema pallidum GN=flaB3 PE=1 SV=3 MIINHNMSAMFAQRQGGINGLAIAKNIEKLSSGYRINRAGDDASGLAVSEKMRSQIRGLN QAGQNIQNGISFIQATEGYLAETTEIVQRLRELAIQAANGIYSAEDRMQIQVEVSQLVDE VDRIASQAQFNGMNLLTGRFSRESALGPMQLHVGANMDQNEKIFINTMTASALGFFSDEG TDGSRSISIATVDGANKVIGTLDSALKEINKQRADLGAYQNRFETAYQGIAIAAENLQAA ESRIRDADLAQQMVDYTKNQILEQSTMAMLAQANTQPQAVLRLMQ
Sequence length 285 AA
Subcellular LocationPeriplasm
Function Flagellar 31 kDa core protein. It is the major component of the endoflagella which are required for motility of Treponemes.
Glycosylation Status
Technique(s) used for Glycosylation DetectionIntrinsic [14C]glucosamine-labeling, periodate oxidation-DIG (digoxigenin) hydrazide labeling
Literature
Year of Identification1984
Year of Identification Month Wise1984.2
ReferenceWyss, C., 1998. Flagellins, but not endoflagellar sheath proteins, of Treponema pallidum and of pathogen-related oral spirochetes are glycosylated. Infection and immunity, 66(12), pp.5751-5754.
Corresponding Author C. Wyss
ContactInstitute for Oral Microbiology and General Immunology, Center for Dentistry, Oral and Maxillofacial Medicine at the University of Zurich, CH-8028 Zurich, Switzerland.
ReferenceMoskophidis, M. and Müller, F., 1985. Identification of glycosylated protein antigens of Treponema pallidum and Treponema phagedenis. Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology, 259(4), pp.468-476.
Corresponding Author Ferdinand Muller
ContactFrom the Department of Medicine, School of Medicine, University of Washington, Seattle,
ReferenceMoskophidis, M.A.T.T.H.A.U.S. and Müller, F., 1984. Molecular characterization of glycoprotein antigens on surface of Treponema pallidum: comparison with nonpathogenic Treponema phagedenis biotype Reiter. Infection and immunity, 46(3), pp.867-869.
Corresponding Author Ferdinand Muller
ContactFrom the Department of Medicine, School of Medicine, University of Washington, Seattle,