ProGP265 (Rv2799)

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ProGP ID ProGP265 (Rv2799)
Validation Status Characterized
Organism Information
Organism NameMycobacterium tuberculosis
Domain Bacteria
Classification Phylum : Actinobacteria
Class : Actinomycetia
Orders : Corynebacteriales
Family : Mycobacteriaceae
Genus : Mycobacterium
Species : tuberculosis
Taxonomic ID (NCBI) 1773
Genome Information
GenBank AL123456.3
EMBL BX842580
Organism Additional Information It is the causative agent of human tuberculosis. The pathogenesis is influenced by its lipoglycans and glycolipids (having a wide range of immunomodulatory activities), and a variety of its virulence factors and antigens.
Gene Information
Gene NameRv2799
NCBI Gene ID 887759
GenBank Gene Sequence NC_000962.3
Protein Information
Protein NameRv2799
UniProtKB/SwissProt ID P71652
NCBI RefSeq NP_217315.1
EMBL-CDSAL123456.3
UniProtKB Sequence >tr|P71652|P71652_MYCTU PROBABLE MEMBRANE PROTEIN OS=Mycobacterium tuberculosis GN=MT2867.1 PE=4 SV=1 MYTPGKGPPRAGGVVFTRVRLIGGLGALTAAVVVVGTVGWQGIPPAPTGGDAVQLRSTAA PMSTTMKSPIVATTDPSPFDPCRDIPFDVIQRLGLAYTPPEAEEGLRCHFDAGNYQMAVE PIIWRTYAQTLPPDAIETTIAGHRAAQYWVRKPTYHNSFWYSSCMVTFKTSYGVIQQSLF YSTVYSEPDVDCPSTNLQRANDLVPYYRF
Sequence length 209 AA
Subcellular LocationMembrane
Glycosylation Status
Glycosylation Type O- (Ser/Thr) linked
Experimentally Validated Glycosite(s) in Full Length ProteinS68, T73, T74 and S77
Glycosite(s) Annotated Protein Sequence >tr|P71652|P71652_MYCTU PROBABLE MEMBRANE PROTEIN OS=Mycobacterium tuberculosis GN=MT2867.1 PE=4 SV=1 MYTPGKGPPRAGGVVFTRVRLIGGLGALTAAVVVVGTVGWQGIPPAPTGGDAVQLRSTAA PMSTTMKS*(68)PIVAT*(73)T*(74)DPS*(77)PFDPCRDIPFDVIQRLGLAYTPPEAEEGLRCHFDAGNYQMAVE PIIWRTYAQTLPPDAIETTIAGHRAAQYWVRKPTYHNSFWYSSCMVTFKTSYGVIQQSLF YSTVYSEPDVDCPSTNLQRANDLVPYYRF
Sequence Around Glycosites (21 AA) TAAPMSTTMKSPIVATTDPSP>STTMKSPIVATTDPSPFDPCR> TTMKSPIVATTDPSPFDPCRD> KSPIVATTDPSPFDPCRDIPF
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Technique(s) used for Glycosylation DetectionConcanavalin A (ConA) binding
Literature
Year of Identification2009
Year of Identification Month Wise2009.02
ReferenceGonzález-Zamorano, M., Mendoza-Hernández, G., Xolalpa, W., Parada, C., Vallecillo, A.J., Bigi, F. and Espitia, C., 2009. Mycobacterium tuberculosis glycoproteomics based on ConA-lectin affinity capture of mannosylated proteins. Journal of proteome research, 8(2), pp.721-733.
Corresponding Author Clara Espitia
ContactImmunology Department, Institute of Biomedical Research, National Autonomous University of Mexico, Mexico.
ReferenceSmith, G.T., Sweredoski, M.J. and Hess, S., 2014. O-linked glycosylation sites profiling in Mycobacterium tuberculosis culture filtrate proteins. Journal of proteomics, 97, pp.296-306.
Corresponding Author Sonja Hess
ContactProteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, CA, USA.