ProGP266 (LprA)

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ProGP ID ProGP266 (LprA)
Validation Status Characterized
Organism Information
Organism NameMycobacterium tuberculosis
Domain Bacteria
Classification Phylum : Actinobacteria
Class : Actinomycetia
Orders : Corynebacteriales
Family : Mycobacteriaceae
Genus : Mycobacterium
Species : tuberculosis
Taxonomic ID (NCBI) 1773
Genome Information
GenBank AL123456.3
EMBL BX842576
Organism Additional Information It is the causative agent of human tuberculosis. The pathogenesis is influenced by its lipoglycans and glycolipids (having a wide range of immunomodulatory activities), and a variety of its virulence factors and antigens.
Gene Information
Gene NamelprA (Rv1270c)
NCBI Gene ID 887017
GenBank Gene Sequence NC_000962.3
Protein Information
Protein NameLprA
UniProtKB/SwissProt ID P9WK55
NCBI RefSeq NP_215786.1
EMBL-CDSAL123456.3
UniProtKB Sequence >sp|P9WK55|LPRA_MYCTU Lipoprotein LprA OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) GN=lprA PE=1 SV=1 MKHPPCSVVAAATAILAVVLAIGGCSTEGDAGKASDTAATASNGDAAMLLKQATDAMRKV TGMHVRLAVTGDVPNLRVTKLEGDISNTPQTVATGSATLLVGNKSEDAKFVYVDGHLYSD LGQPGTYTDFGNGASIYNVSVLLDPNKGLANLLANLKDASVAGSQQADGVATTKITGNSS ADDIATLAGSRLTSEDVKTVPTTVWIASDGSSHLVQIQIAPTKDTSVTLTMSDWGKQVTA TKPV
Sequence length 244 AA
Subcellular LocationMembrane
Function Putative lipoprotein
Glycosylation Status
Glycosylation Type O- (Ser/Thr) linked
Experimentally Validated Glycosite(s) in Full Length ProteinS35, T37, T40 and S42
Glycosite(s) Annotated Protein Sequence >sp|Q11049|LPRA_MYCTU Putative lipoprotein lprA OS=Mycobacterium tuberculosis GN=lprA PE=1 SV=2 MKHPPCSVVAAATAILAVVLAIGGCSTEGDAGKAS*(35)DT*(37)AAT*(40)AS*(42)NGDAAMLLKQATDAMRKV TGMHVRLAVTGDVPNLRVTKLEGDISNTPQTVATGSATLLVGNKSEDAKFVYVDGHLYSD LGQPGTYTDFGNGASIYNVSVLLDPNKGLANLLANLKDASVAGSQQADGVATTKITGNSS ADDIATLAGSRLTSEDVKTVPTTVWIASDGSSHLVQIQIAPTKDTSVTLTMSDWGKQVTA TKPV
Sequence Around Glycosites (21 AA) CSTEGDAGKASDTAATASNGD
TEGDAGKASDTAATASNGDAA
DAGKASDTAATASNGDAAMLL
GKASDTAATASNGDAAMLLKQ
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Technique(s) used for Glycosylation DetectionConcanavalin A (ConA) binding
Literature
Year of Identification2009
Year of Identification Month Wise2009.02
ReferenceGonzález-Zamorano, M., Mendoza-Hernández, G., Xolalpa, W., Parada, C., Vallecillo, A.J., Bigi, F. and Espitia, C., 2009. Mycobacterium tuberculosis glycoproteomics based on ConA-lectin affinity capture of mannosylated proteins. Journal of proteome research, 8(2), pp.721-733.
Corresponding Author Clara Espitia
ContactImmunology Department, Institute of Biomedical Research, National Autonomous University of Mexico, Mexico.
ReferenceSmith, G.T., Sweredoski, M.J. and Hess, S., 2014. O-linked glycosylation sites profiling in Mycobacterium tuberculosis culture filtrate proteins. Journal of proteomics, 97, pp.296-306.
Corresponding Author Sonja Hess
ContactProteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, CA, USA.