ProGP318 (BF3918)
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ProGP ID | ProGP318 (BF3918) |
Validation Status | Uncharacterized |
Organism Information | |
Organism Name | Bacteroides fragilis |
Domain | Bacteria |
Classification | Phylum : Bacteroidetes Class : Bacteroidia Orders : Bacteroidales Family : Bacteroidaceae Genus : Bacteroides Species : fragilis |
Taxonomic ID (NCBI) | 272559 |
Genome Information | |
GenBank | CR626927.1 |
EMBL | CR626927 |
Organism Additional Information | The Bacteroides constitute the major population of human intestinal microbiota. They are beneficial to the humans in terms of metabolism, development, and immunity. They play roles in recycling of bile acids, provision of short-chain fatty acids to the host and angiogenesis. |
Gene Information | |
Gene Name | pepO (BF3918) |
GenBank Gene Sequence | NC_003228.3 |
Protein Information | |
Protein Name | BF3918 |
UniProtKB/SwissProt ID | Q5L8J2 |
NCBI RefSeq | WP_010993651.1 |
EMBL-CDS | CAH09595.1 |
UniProtKB Sequence | >tr|Q5L8J2|Q5L8J2_BACFN Putative endopeptidase OS=Bacteroides fragilis (strain ATCC 25285 / NCTC 9343) GN=pepO PE=4 SV=1 MKVIKYLPILAICCMATGCNSKKEAVLTSGIDLANLDTTALPGTSFYQYACGGWMKNHPL TDEYSRFGSFDMLAENNRQQLRGLIEGLAAEKHEAGSIAQKVGELYNIAMDSVKLNKEGA APIKPELEKIGAIKDKAEIYPLIVEMQKRGMYPYFILYVSADDMNSNENMVHTMQGGLGM GERDYYLEDDAQTKEIRDKYQQHVSKMFQLAGYDEATARKAVKAVMNIETRLAQSARSQV ELRDPHANYNKKTLEELQKEYPSFAWDVFFSTAGLNNLKEVNIGQPDALKEVNAIIDTVS LEDQILYLQWNLINSAANYLSDDFIAQDFDFYGRTMSGKKEMQPRWKRAVSTVDGSLGEA VGQMYVEKYFPAAAKERMVALVKNLQESLGERIKGLSWMGEETKEKALEKLATFHVKIGY PDKWKDYSSLEIKDDSYWANIERANQWSYNEMIGKYGKPVDKDEWYMTPQTVNAYYNPTT NEICFPAGILQYPFFDMNADDAFNYGAIGVVIGHEMTHGFDDQGRQYDKDGNLKDWWTAE DAKNFEARAAVMANFFDSIEVAPGVHANGEFTLGENIADHGGLQVSYQAFKKATAAAPLK IENGFTPEQRFFLSYANVWAGNIRPEEILKRTKTDPHSLGKWRVDGALPQIGAWYEAFNI TEKDPMYLPVDKRVSIW |
Sequence length | 677 AA |
Subcellular Location | Outer membrane - facing periplasm |
Function | Zinc endopeptidase (M13 family). |
Glycosylation Status | |
Technique(s) used for Glycosylation Detection | Mass shift detected on SDS-polyacrylamide gel, AAL (Aleuria aurantia lectin) reactivity, Pro-Q Emerald Glycostaining and reactivity towards anti-glycan antiserum |
Glycan Information | |
Glycan Annotation | Exogenous fucose. |
Literature | |
Year of Identification | 2009 |
Year of Identification Month Wise | 2009.4 |
Reference | Fletcher, C.M., Coyne, M.J., Villa, O.F., Chatzidaki-Livanis, M. and Comstock, L.E., 2009. A general O-glycosylation system important to the physiology of a major human intestinal symbiont. Cell, 137(2), pp.321-331. |
Corresponding Author | Laurie E. Comstock |
Contact | Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. |