ProGP327 (LccA, an Archaeal Laccase)
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| ProGP ID | ProGP327 (LccA, an Archaeal Laccase) |
| Validation Status | Uncharacterized |
| Organism Information | |
| Organism Name | Haloferax volcanii DS2 |
| Domain | Archaea |
| Classification | Phylum : Euryarchaeota Class : Halobacteria Orders : Haloferacales Family : Haloferacaceae Genus : Haloferax Species : volcanii Strain : DS2 |
| Taxonomic ID (NCBI) | 309800 |
| Genome Information | |
| GenBank | CP001953.1 |
| EMBL | CP001953 |
| Gene Information | |
| Gene Name | lccA |
| NCBI Gene ID | 8919198 |
| GenBank Gene Sequence | NC_013964 |
| Protein Information | |
| Protein Name | LccA, an Archaeal Laccase |
| UniProtKB/SwissProt ID | D4GPK6 |
| NCBI RefSeq | WP_013034979.1 |
| EMBL-CDS | ADE01515.1 |
| UniProtKB Sequence | >tr|D4GPK6|D4GPK6_HALVD LccA multicopper oxidase (MCO) OS=Haloferax volcanii (strain ATCC 29605 / DSM 3757 / IFO 14742 / NCIMB 2012 / DS2) GN=lccA PE=4 SV=1 MTDWSRRRFLQTGAALGIAGTLPQTTTEVSAASPTLEKFVQPLPIPSVREPDGQRDGADA YEIAVTEFTQQLHPDLPETTVWGFDGSYPGPTIEADAGSPVHVRFDNSGLPSEHLFPVDD RLGGTTAENHPGYDGPVPEVRTVTHFHGLELDPANDGQSDMWTSPGGVEGPRFDSAWQEL PMEQGRTTSTYHDHTLGITRLNAYAGLLGLYSITTDAERELGLPSGDYDIPLLLQDKEFN DDGSLHYPEEFVSAFLGDTAVVNGAVWPYVEVEPRRYRFRILNGANHRSFDLQLESESGS GVPTMYQFAPGHGFLESVVPIGPNGDLDSLLLTPFERGELVVDFSDHAGETLTLANGADM GPELTDLVEFRVSDPSTPPEDASADPTSLSLPTPASYDESDARVTREMTLGTEVRNGLIT HTLNGHVFGDEDAPVYPQLGATEIWELQNESGGRHPIHLHLVTFRVIGRGPDGTQPPDPN ELGPKDTVRVDPGERVRILVTFEGYTGQFPWHCHMLEHEDNKMMIPFVVENPVADYANEE NVVDATGLTDAVGDWRNETLETEVLLEVIDQWRSGDEVA |
| Sequence length | 579 AA |
| Subcellular Location | Secreted |
| Function | Belongs to the family of Multicopper oxidases (MCOs). Laccases couple the oxidation of phenolic compounds to the reduction of O2. |
| Glycosylation Status | |
| Technique(s) used for Glycosylation Detection | Carbohydrate content determined by phenol-sulfuric acid assay, Pro-Q Emerald 300 staining and mass shift (of 10-20 kDa) detected after deglycosylation with TFMS (trifluoromethanesulfonic acid). |
| Literature | |
| Year of Identification | 2010 |
| Year of Identification Month Wise | 2010.2 |
| Reference | Uthandi, S., Saad, B., Humbard, M.A. and Maupin-Furlow, J.A., 2010. LccA, an archaeal laccase secreted as a highly stable glycoprotein into the extracellular medium by Haloferax volcanii. Applied and environmental microbiology, 76(3), pp.733-743. |
| Corresponding Author | Julie A. Maupin-Furlow |
| Contact | Department of Microbiology and Cell Science, University of Florida, Gainesville, FL 32611-0700, USA. |