ProGP349 (TF1259)
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| ProGP ID | ProGP349 (TF1259) |
| Validation Status | Characterized |
| Organism Information | |
| Organism Name | Tannerella forsythia ATCC 43037 |
| Domain | Bacteria |
| Classification | Phylum : Bacteroidetes Class : Bacteroidia Orders : Bacteroidales Family : Tanerellaceae Genus : Tannerella Species : forsythia Strain : ATCC 43037 |
| Taxonomic ID (NCBI) | 203275 |
| Genome Information | |
| GenBank | GQ856797 |
| EMBL | GQ856797 |
| Organism Additional Information | Tannerella forsythia is an oral pathogen causing chronic periodontitis. It forms polymicrobial subgingival plaque biofilm along with Porphyromonas gingivalis and Treponema denticola. |
| Gene Information | |
| Gene Name | TF1259 (Tanf_08965) |
| GenBank Gene Sequence | JUET01000092.1 |
| Protein Information | |
| Protein Name | TF1259 |
| NCBI RefSeq | KKY61076.1 |
| EMBL-CDS | KKY61076.1 |
| UniProtKB Sequence | >UPI00062B1A4A status=active MAHKDNPGNLDHGNPYFTQSQFNNLPVQNKTNGNMYLDKGSGTEYSFLNTANLPLSYYTN IHALYDKTPVSLLGVKGNYDEDNAIIHTSSTGTDNHKGVIEVGSRTTGQQRFKVYSGGVI KNYSTTACNGEACAGVFFKSGNVPEFIIKGTEPLYILNDGNCCEAAITFFNGGTAALVSA VQGANATGDLLIRAHGEVRIQDNADFDATAKNNNVSILSDQSHISTKAFGYTAAGASDLG HLTLWAKGDTFIINTPNNCGGYVSIEGNLTTTSTSTGSTWQTLTDAVQRNSGKLARRTNC SSFGEEMAARAPSALETGVQTRIQSDRDYVKVTGDFKHIGQNGGLFVQGAGKVTVNGKTE IDFKTKDGIGDAVIQSKNSSVWFNNEFSYTGNVTTDLFIDGEKGVTFNSVSGPSTIDYTQ GTDPSAHIGIQSNAGTIAFKNKAFTFKSKSTGETQLWAGANITSTDNAPLLFEYTVRNDG QNIDWYAGRDIDLSGTLTFKHDDAKDHTGFIKLRANANEAELWNHNSTDPTGRPGAGICP EICDHSDNGIHGNIYLRNDVKVNYWGKENVWMAANHDIHIQRNYTHVAGGAGQDPQGFTR FVAGNDIVTGKIGDPNSTFSYLHVGEKGERIRHFDMKAGHDIITHNHVKIGYNAATDDAF NTTLFACNDIDIRNSFWYADSSTTNKGKWTRLYANRDILSNQTCLNYGAPINFYTPDNTK TEWNVGRNIITGDTVNFRYGNTQKKVSNLSLVAQGGNIEMRRWTNINYDSDSLILISAER NKDYSVAKAAGLTANGHKSNGGSPDNARFIHDGHIYSNDSLKITRTNDEDGKTGIYADYH IRTAMVNILDSSAMNKNNTAIESHLGDIWLGYSVSPYPCPTPGQTTLGYDINRFIYKNLG STNNQSLLIRAGYQDQSNTTRYGGGNIYVAQMKNELTTGGTTDTEISIPFSNEYLCGSTW SPDFLYNRKDSSMMMYEHAGIIFGLGRCGEDKNIDKYAPAQNLASGNKVTKTSLIYRGNK GNLKVDAGTRGNIILNKGGLINFQDPQNTGNVTFRTRFGDIDMRDPFNADSIAGSLLFLA QTENLSDLSKVGYCGCEEERNNVYLQDFQYKAHGASGSIFVGADNNIKLNYGGLQNKGTR YDPFLSTDYLACPDSSVAKIGSGYQRGGGCGPMYHCDMHDSVNQARNLILNFYQDSTNTD ITSGGFAAVASDYIDVYKSLIYKGGNGSGMSAVPGAGTLHGESVAGYGLYMKTQANKNNW NTNIFKNYPKCPMGCSGFECNGGFLHMISRMTFHADARIYAHNQRVYLGSPVIESFGPMV LNTDSMSGGRTEIVIQTDSLILHDSLVVKGKKLRYRSWSGLKNDRPIIKFGYMRRTPPFT EYTKNVCGADLDVCEPCHDYIRGSKDPVHMLDTITIKFEEGAYLERLNSVVFDHTVLTFL TDSFDHVQGPPVEHARIYVDTLRVRNQVDLYADAKHERDAHFELISEEQMSSKKYAGVYT RHYHMEPVGACGRNYSELWLSDDLALDVITTSTFGGFGYQHSDVHVENMAHLNPGFTSLR LR |
| Sequence length | 1562 AA |
| Function | Outer membrane protein |
| Glycosylation Status | |
| Glycosylation Type | O- (Thr) linked |
| Experimentally Validated Glycosite(s) in Full Length Protein | T1082 |
| Glycosite(s) Annotated Protein Sequence | >KKY61076.1 hypothetical protein Tanf_08965, partial [Tannerella forsythia] MAHKDNPGNLDHGNPYFTQSQFNNLPVQNKTNGNMYLDKGSGTEYSFLNTANLPLSYYTNIHALYDKTPV SLLGVKGNYDEDNAIIHTSSTGTDNHKGVIEVGSRTTGQQRFKVYSGGVIKNYSTTACNGEACAGVFFKS GNVPEFIIKGTEPLYILNDGNCCEAAITFFNGGTAALVSAVQGANATGDLLIRAHGEVRIQDNADFDATA KNNNVSILSDQSHISTKAFGYTAAGASDLGHLTLWAKGDTFIINTPNNCGGYVSIEGNLTTTSTSTGSTW QTLTDAVQRNSGKLARRTNCSSFGEEMAARAPSALETGVQTRIQSDRDYVKVTGDFKHIGQNGGLFVQGA GKVTVNGKTEIDFKTKDGIGDAVIQSKNSSVWFNNEFSYTGNVTTDLFIDGEKGVTFNSVSGPSTIDYTQ GTDPSAHIGIQSNAGTIAFKNKAFTFKSKSTGETQLWAGANITSTDNAPLLFEYTVRNDGQNIDWYAGRD IDLSGTLTFKHDDAKDHTGFIKLRANANEAELWNHNSTDPTGRPGAGICPEICDHSDNGIHGNIYLRNDV KVNYWGKENVWMAANHDIHIQRNYTHVAGGAGQDPQGFTRFVAGNDIVTGKIGDPNSTFSYLHVGEKGER IRHFDMKAGHDIITHNHVKIGYNAATDDAFNTTLFACNDIDIRNSFWYADSSTTNKGKWTRLYANRDILS NQTCLNYGAPINFYTPDNTKTEWNVGRNIITGDTVNFRYGNTQKKVSNLSLVAQGGNIEMRRWTNINYDS DSLILISAERNKDYSVAKAAGLTANGHKSNGGSPDNARFIHDGHIYSNDSLKITRTNDEDGKTGIYADYH IRTAMVNILDSSAMNKNNTAIESHLGDIWLGYSVSPYPCPTPGQTTLGYDINRFIYKNLGSTNNQSLLIR AGYQDQSNTTRYGGGNIYVAQMKNELTTGGTTDTEISIPFSNEYLCGSTWSPDFLYNRKDSSMMMYEHAG IIFGLGRCGEDKNIDKYAPAQNLASGNKVTKTSLIYRGNKGNLKVDAGTRGNIILNKGGLINFQDPQNTG NVTFRTRFGDIDMRDPFNADSIAGSLLFLAQT*(1082)ENLSDLSKVGYCGCEEERNNVYLQDFQYKAHGASGSIF VGADNNIKLNYGGLQNKGTRYDPFLSTDYLACPDSSVAKIGSGYQRGGGCGPMYHCDMHDSVNQARNLIL NFYQDSTNTDITSGGFAAVASDYIDVYKSLIYKGGNGSGMSAVPGAGTLHGESVAGYGLYMKTQANKNNW NTNIFKNYPKCPMGCSGFECNGGFLHMISRMTFHADARIYAHNQRVYLGSPVIESFGPMVLNTDSMSGGR TEIVIQTDSLILHDSLVVKGKKLRYRSWSGLKNDRPIIKFGYMRRTPPFTEYTKNVCGADLDVCEPCHDY IRGSKDPVHMLDTITIKFEEGAYLERLNSVVFDHTVLTFLTDSFDHVQGPPVEHARIYVDTLRVRNQVDL YADAKHERDAHFELISEEQMSSKKYAGVYTRHYHMEPVGACGRNYSELWLSDDLALDVITTSTFGGFGYQ HSDVHVENMAHLNPGFTSLRLR |
| Sequence Around Glycosites (21 AA) | IAGSLLFLAQTENLSDLSKVG |
| Technique(s) used for Glycosylation Detection | Pro-Q Emerald carbohydrate staining |
| Glycan Information | |
| Glycan Annotation | An oligosaccharide with the structure 4-Me-β-ManpNAcCONH2-(1→3)-[Pse5Am7Gc-(2→4)-]-β-ManpNAcA-(1→4)-[4-Me-α-Galp-(1→2)-]-α-Fucp-(1→4)-[-α-Xylp-(1→3)-]-β-GlcpA-(1→3)-[-β-Digp-(1→2)-]-α-Galp. |
| GlyTouCan | G58135UN |
| Literature | |
| Year of Identification | 2011 |
| Year of Identification Month Wise | 2011.2.4 |
| Year of Validation | 2011 |
| Reference | Posch, G., Pabst, M., Brecker, L., Altmann, F., Messner, P. and Schäffer, C., 2011. Characterization and scope of S-layer protein O-glycosylation in Tannerella forsythia. Journal of Biological Chemistry, 286(44), pp.38714-38724. |
| Corresponding Author | Christina Schaffer |
| Contact | Department of NanoBiotechnology, NanoGlycobiology, Vienna Institute of BioTechnology, Universität für Bodenkultur Wien, Muthgasse 11, A-1190 Vienna, Austria. |