ProGP454 (Rv1887)
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| ProGP ID | ProGP454 (Rv1887) | ||||||||||||||||||||||||
| Validation Status | Characterized | ||||||||||||||||||||||||
| Organism Information | |||||||||||||||||||||||||
| Organism Name | Mycobacterium tuberculosis H37Rv | ||||||||||||||||||||||||
| Domain | Bacteria | ||||||||||||||||||||||||
| Classification | Family: Mycobacteriaceae Suborder: Corynebacterineae Order: Actinomycetales Subclass: Actinobacteridae Class: Actinobacteria Division or phylum: "Actinobacteria" | ||||||||||||||||||||||||
| Taxonomic ID (NCBI) | 83332 | ||||||||||||||||||||||||
| Genome Information | |||||||||||||||||||||||||
| GenBank | NC_000962.3 | ||||||||||||||||||||||||
| EMBL | CP009480 | ||||||||||||||||||||||||
| Organism Additional Information | It is the causative agent of human tuberculosis. The pathogenesis is influenced by its lipoglycans and glycolipids (having a wide range of immunomodulatory activities), and a variety of its virulence factors and antigens. | ||||||||||||||||||||||||
| Gene Information | |||||||||||||||||||||||||
| Gene Name | Rv1887 | ||||||||||||||||||||||||
| NCBI Gene ID | 885247 | ||||||||||||||||||||||||
| GenBank Gene Sequence | NC_000962.3 | ||||||||||||||||||||||||
| Protein Information | |||||||||||||||||||||||||
| Protein Name | Rv1887 | ||||||||||||||||||||||||
| UniProtKB/SwissProt ID | O07745 | ||||||||||||||||||||||||
| NCBI RefSeq | NP_216403.1" | ||||||||||||||||||||||||
| EMBL-CDS | CCP44653.1. | ||||||||||||||||||||||||
| UniProtKB Sequence | >tr|O07745|O07745_MYCTU Membrane protein OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) GN=Rv1887 PE=1 SV=3 MDTVLGLSITPTTLGWVLAEGHGADGAILDRNELELHSGRNAQAIHTAEQLAAEVLLAHE VAAAGDHRLRVIGVTWNAEASAQAALLVESLTGAGFDNVVPVRRLRAIETLAQAIAPVIG YEQIAVCVLEHESATVVMVDTHDGKTQIAVKHVCRGLSGLTSWLTGMFGRDAWRPAGVVV VGSDSEVSEFSWQLERVLPVPVFAQTMAQVTVARGAALAAAQSTEFTDAQLVADSVSQPT VAPRRSRHYAGAAAALAAAAVTFVASLSLAVGIQLAPHNDTGTAKHGAHKPTPRIAKAVA PAVPPPPTVTPPVPARAPRPAAQHEPPARVTSGEALTEPNPPEEQPNASAPQQDRNDSQP ITRVLEHIPGAYGDSAPPAE | ||||||||||||||||||||||||
| Sequence length | 380 AA | ||||||||||||||||||||||||
| Subcellular Location | Membrane | ||||||||||||||||||||||||
| Glycosylation Status | |||||||||||||||||||||||||
| Glycosylation Type | O- (Thr) linked | ||||||||||||||||||||||||
| Experimentally Validated Glycosite(s) in Full Length Protein | T308 and T310 | ||||||||||||||||||||||||
| Glycosite(s) Annotated Protein Sequence | >tr|O07745|O07745_MYCTU Membrane protein OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) GN=Rv1887 PE=1 SV=3 MDTVLGLSITPTTLGWVLAEGHGADGAILDRNELELHSGRNAQAIHTAEQLAAEVLLAHE VAAAGDHRLRVIGVTWNAEASAQAALLVESLTGAGFDNVVPVRRLRAIETLAQAIAPVIG YEQIAVCVLEHESATVVMVDTHDGKTQIAVKHVCRGLSGLTSWLTGMFGRDAWRPAGVVV VGSDSEVSEFSWQLERVLPVPVFAQTMAQVTVARGAALAAAQSTEFTDAQLVADSVSQPT VAPRRSRHYAGAAAALAAAAVTFVASLSLAVGIQLAPHNDTGTAKHGAHKPTPRIAKAVA PAVPPPPT*(308)VT*(310)PPVPARAPRPAAQHEPPARVTSGEALTEPNPPEEQPNASAPQQDRNDSQP ITRVLEHIPGAYGDSAPPAE | ||||||||||||||||||||||||
| Sequence Around Glycosites (21 AA) | AVAPAVPPPPTVTPPVPARAP APAVPPPPTVTPPVPARAPRP | ||||||||||||||||||||||||
| Average Amino Acid Composition around Glycosite(s) | _AVAPAVPPPPT(he)VT(he)PPVPAR__AVAPAVPPPPT(he)VT(he)PPVPAR_ | ||||||||||||||||||||||||
| ProGP Web Logo |  Technique(s) used for Glycosylation Detection | LC-MS (CID) | Technique(s) used for Glycosylated Residue(s) Detection | CID | Glycan Information | Glycan Annotation | Hex | Literature | Year of Identification | 2014 | Year of Identification Month Wise | 2014.1.31 | Reference | Smith GT, Sweredoski MJ, Hess S (2014) O-linked glycosylation sites profiling in Mycobacterium tuberculosis culture filtrate proteins.J Proteomics, 97:296-306. [PubMed: 23702328] | Author | Smith, Geoffrey T., Michael J. Sweredoski, and Sonja Hess. | Research Group | Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, CA, USA | Corresponding Author | Sonja Hess. | Contact | Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, CA, USA | | ||
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