ProGP454 (Rv1887)
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| ProGP ID | ProGP454 (Rv1887) | ||||||||||||||||||||
| Validation Status | Characterized | ||||||||||||||||||||
| Organism Information | |||||||||||||||||||||
| Organism Name | Mycobacterium tuberculosis H37Rv | ||||||||||||||||||||
| Domain | Bacteria | ||||||||||||||||||||
| Classification | Phylum : Actinobacteria Class : Actinomycetia Orders : Corynebacteriales Family : Mycobacteriaceae Genus : Mycobacterium Species : tuberculosis Strain : H37Rv | ||||||||||||||||||||
| Taxonomic ID (NCBI) | 83332 | ||||||||||||||||||||
| Genome Information | |||||||||||||||||||||
| GenBank | NC_000962.3 | ||||||||||||||||||||
| EMBL | CP009480 | ||||||||||||||||||||
| Organism Additional Information | It is the causative agent of human tuberculosis. The pathogenesis is influenced by its lipoglycans and glycolipids (having a wide range of immunomodulatory activities), and a variety of its virulence factors and antigens. | ||||||||||||||||||||
| Gene Information | |||||||||||||||||||||
| Gene Name | Rv1887 | ||||||||||||||||||||
| NCBI Gene ID | 885247 | ||||||||||||||||||||
| GenBank Gene Sequence | NC_000962.3 | ||||||||||||||||||||
| Protein Information | |||||||||||||||||||||
| Protein Name | Rv1887 | ||||||||||||||||||||
| UniProtKB/SwissProt ID | O07745 | ||||||||||||||||||||
| NCBI RefSeq | NP_216403.1 | ||||||||||||||||||||
| EMBL-CDS | CCP44653.1 | ||||||||||||||||||||
| UniProtKB Sequence | >tr|O07745|O07745_MYCTU Membrane protein OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) GN=Rv1887 PE=1 SV=3 MDTVLGLSITPTTLGWVLAEGHGADGAILDRNELELHSGRNAQAIHTAEQLAAEVLLAHE VAAAGDHRLRVIGVTWNAEASAQAALLVESLTGAGFDNVVPVRRLRAIETLAQAIAPVIG YEQIAVCVLEHESATVVMVDTHDGKTQIAVKHVCRGLSGLTSWLTGMFGRDAWRPAGVVV VGSDSEVSEFSWQLERVLPVPVFAQTMAQVTVARGAALAAAQSTEFTDAQLVADSVSQPT VAPRRSRHYAGAAAALAAAAVTFVASLSLAVGIQLAPHNDTGTAKHGAHKPTPRIAKAVA PAVPPPPTVTPPVPARAPRPAAQHEPPARVTSGEALTEPNPPEEQPNASAPQQDRNDSQP ITRVLEHIPGAYGDSAPPAE | ||||||||||||||||||||
| Sequence length | 380 AA | ||||||||||||||||||||
| Subcellular Location | Membrane | ||||||||||||||||||||
| Glycosylation Status | |||||||||||||||||||||
| Glycosylation Type | O- (Thr) linked | ||||||||||||||||||||
| Experimentally Validated Glycosite(s) in Full Length Protein | T308 and T310 | ||||||||||||||||||||
| Glycosite(s) Annotated Protein Sequence | >tr|O07745|O07745_MYCTU Membrane protein OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) GN=Rv1887 PE=1 SV=3 MDTVLGLSITPTTLGWVLAEGHGADGAILDRNELELHSGRNAQAIHTAEQLAAEVLLAHE VAAAGDHRLRVIGVTWNAEASAQAALLVESLTGAGFDNVVPVRRLRAIETLAQAIAPVIG YEQIAVCVLEHESATVVMVDTHDGKTQIAVKHVCRGLSGLTSWLTGMFGRDAWRPAGVVV VGSDSEVSEFSWQLERVLPVPVFAQTMAQVTVARGAALAAAQSTEFTDAQLVADSVSQPT VAPRRSRHYAGAAAALAAAAVTFVASLSLAVGIQLAPHNDTGTAKHGAHKPTPRIAKAVA PAVPPPPT*(308)VT*(310)PPVPARAPRPAAQHEPPARVTSGEALTEPNPPEEQPNASAPQQDRNDSQP ITRVLEHIPGAYGDSAPPAE | ||||||||||||||||||||
| Sequence Around Glycosites (21 AA) | AVAPAVPPPPTVTPPVPARAP APAVPPPPTVTPPVPARAPRP | ||||||||||||||||||||
| Average Amino Acid Composition around Glycosite(s) | _AVAPAVPPPPT(he)VT(he)PPVPAR__AVAPAVPPPPT(he)VT(he)PPVPAR_ | ||||||||||||||||||||
| ProGP Web Logo |  Technique(s) used for Glycosylation Detection | LC-MS (CID) | Technique(s) used for Glycosylated Residue(s) Detection | CID | Glycan Information | Glycan Annotation | Hex | Literature | Year of Identification | 2014 | Year of Identification Month Wise | 2014.1.31 | Reference | Smith, G.T., Sweredoski, M.J. and Hess, S., 2014. O-linked glycosylation sites profiling in Mycobacterium tuberculosis culture filtrate proteins. Journal of proteomics, 97, pp.296-306. | Corresponding Author | Sonja Hess | Contact | Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, CA, USA | | ||
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