ProGP456 (Rv3835)
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| ProGP ID | ProGP456 (Rv3835) |
| Validation Status | Characterized |
| Organism Information | |
| Organism Name | Mycobacterium tuberculosis H37Rv |
| Domain | Bacteria |
| Classification | Phylum : Actinobacteria Class : Actinomycetia Orders : Corynebacteriales Family : Mycobacteriaceae Genus : Mycobacterium Species : tuberculosis Strain : H37Rv |
| Taxonomic ID (NCBI) | 83332 |
| Genome Information | |
| GenBank | NC_000962.3 |
| EMBL | CP009480 |
| Organism Additional Information | It is the causative agent of human tuberculosis. The pathogenesis is influenced by its lipoglycans and glycolipids (having a wide range of immunomodulatory activities), and a variety of its virulence factors and antigens. |
| Gene Information | |
| Gene Name | Rv3835 |
| NCBI Gene ID | 886168 |
| GenBank Gene Sequence | NC_000962.3 |
| Protein Information | |
| Protein Name | Rv3835 |
| UniProtKB/SwissProt ID | P96243/P9WKW5 |
| NCBI RefSeq | NP_218352 |
| EMBL-CDS | CCP46664.3 |
| UniProtKB Sequence | >sp|P9WKW5|Y3835_MYCTU Uncharacterized membrane protein Rv3835 OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) GN=Rv3835 PE=1 SV=1 AIPAVGRAPERLAGYIASNPVPSTGAKINASFNRVASGDCLMWPDGTPESAAIVSCADEHMLDAPEQDPVDPGDPASPPHGEAEQPLPGPRWPRALRASATRRALLLTALGGLLIAGLVTRFEVAESIDMRTFPGMEYGQNAAPPSPARIQQISEEQCEAAVRRYLGTKFDPNSKFTISMLWPGDRAWRQAGERRMLCGLQSPGPNNQQLAFKGKVADIDQSKVWPAGTCLGIDATTNQPIDVPVDCAAPHAMEVSGTVNLAERFPDALPSEPEQDGFIKDACTRMTDAYLAPLKLRTTTLTLIYPTLTLPSWSAGSRVVACSIGATLGNGGWATLVNSAKGALLINGQPPVPPPDIPEERLNLPPIPLQLPTPRPAPPAQQLPSTPPGTQHLPAQQPVVTPTRPPESHAPASAAPAETQPPPPDAGAPPATQSPEATPPGPAEPAPAG |
| Sequence length | 449 AA |
| Subcellular Location | Membrane |
| Glycosylation Status | |
| Glycosylation Type | O- (Thr) linked |
| Experimentally Validated Glycosite(s) in Full Length Protein | T373 |
| Glycosite(s) Annotated Protein Sequence | >sp|P9WKW5|Y3835_MYCTU Uncharacterized membrane protein Rv3835 OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) GN=Rv3835 PE=1 SV=1 AIPAVGRAPERLAGYIASNPVPSTGAKINASFNRVASGDCLMWPDGTPESAAIVSCADEHMLDAPEQDPVDPGDPASPPHGEAEQPLPGPRWPRALRASATRRALLLTALGGLLIAGLVTRFEVAESIDMRTFPGMEYGQNAAPPSPARIQQISEEQCEAAVRRYLGTKFDPNSKFTISMLWPGDRAWRQAGERRMLCGLQSPGPNNQQLAFKGKVADIDQSKVWPAGTCLGIDATTNQPIDVPVDCAAPHAMEVSGTVNLAERFPDALPSEPEQDGFIKDACTRMTDAYLAPLKLRTTTLTLIYPTLTLPSWSAGSRVVACSIGATLGNGGWATLVNSAKGALLINGQPPVPPPDIPEERLNLPPIPLQLPT*(373)PRPAPPAQQLPSTPPGTQHLPAQQPVVTPTRPPESHAPASAAPAETQPPPPDAGAPPATQSPEATPPGPAEPAPAG |
| Sequence Around Glycosites (21 AA) | SGRSIQNKGITPDVPVDQYAD |
| Average Amino Acid Composition around Glycosite(s) | LNLPPIPLQLPT(he)PR |
| Technique(s) used for Glycosylation Detection | LC-MS (CID) |
| Technique(s) used for Glycosylated Residue(s) Detection | neutral loss MS3, (CID) |
| Glycan Information | |
| Glycan Annotation | Hex |
| Literature | |
| Year of Identification | 2014 |
| Year of Identification Month Wise | 2014.1.31 |
| Reference | Smith, G.T., Sweredoski, M.J. and Hess, S., 2014. O-linked glycosylation sites profiling in Mycobacterium tuberculosis culture filtrate proteins. Journal of proteomics, 97, pp.296-306. |
| Corresponding Author | Sonja Hess |
| Contact | Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, CA, USA |