ProGP469 (MdtA multidrug resistance protein)
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ProGP ID | ProGP469 (MdtA multidrug resistance protein) |
Validation Status | Characterized |
Organism Information | |
Organism Name | Burkholderia cenocepacia K56-2 |
Domain | Bacteria |
Classification | Family: Burkholderiaceae Order: Burkholderiales Class: Betaproteobacteria Division or phylum: "Proteobacteria" |
Taxonomic ID (NCBI) | 985075 |
Genome Information | |
GenBank | NZ_LAUA01000000 |
EMBL | LAUA01000000 |
Organism Additional Information | Burkholderia cenocepacia causes opportunistic infections in plants, insects, animals and humans. It acts as a health threat to cystic fibrosis patients, causing lethal necrotizing pneumonia in some cases. |
Gene Information | |
Gene Name | bcal1081 |
GenBank Gene Sequence | NC_011000.1. |
Protein Information | |
Protein Name | MdtA multidrug resistance protein |
UniProtKB/SwissProt ID | B4ED17 |
NCBI RefSeq | WP_006493330.1. |
EMBL-CDS | CAR51384.1 |
UniProtKB Sequence | >tr|B4ED17|B4ED17_BURCJ Multidrug resistance protein MdtA OS=Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) GN=mdtA PE=3 SV=1 MDNEQKPTPPSKDPAPAAARRPRRTLLLGTVAVVVIGGLLWWHPWNRTPAAGSSAQGAGA SAAAGSHRGRGGPAAMANVPQPVQVATATQGEMPIVLSALGTVTPLANVTVKTQLSGYLQ SVSFQEGQIVKKGDVLAQIDPRPYQVALENAEGTHARDAALLATARLDLKRYQTLLSQDS IASQTVDTQASLVKQYEGAVKTDQAAIDSAKLNLTYARITAPVSGRVGLRQVDPGNYVTP GDTNGIVVITQLQPMSVIFTTSEDNLPQILKQVNAGRKLSVTAYNRNNTVPLETGSLATL DNQIDTSTGTVKLRANFDNKEGMLFPNQFVNTRLLVDVLRNATIVPTSAVLTGSIGQFVY VVKPDNTVTVRKVTIGPVDGERTSIVSGVMLGERVVTDGSDRLREGSKISIPADKPKGAS GAHGAGAASGASAASGAAGHRGGHRHGASQAAAPAAQ |
Sequence length | 457 AA |
Subcellular Location | Inner membrane |
Function | Membrane fusion protein spanning the periplasm. Component of RND (resistance, nodulation, division) transporters, involved in transmembrane transport. |
Glycosylation Status | |
Glycosylation Type | O- (Ser/Thr) linked |
Experimentally Validated Glycosite(s) in Full Length Protein | S449 |
Glycosite(s) Annotated Protein Sequence | >tr|B4ED17|B4ED17_BURCJ Multidrug resistance protein MdtA OS=Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) GN=mdtA PE=3 SV=1 MDNEQKPTPPSKDPAPAAARRPRRTLLLGTVAVVVIGGLLWWHPWNRTPAAGSSAQGAGA SAAAGSHRGRGGPAAMANVPQPVQVATATQGEMPIVLSALGTVTPLANVTVKTQLSGYLQ SVSFQEGQIVKKGDVLAQIDPRPYQVALENAEGTHARDAALLATARLDLKRYQTLLSQDS IASQTVDTQASLVKQYEGAVKTDQAAIDSAKLNLTYARITAPVSGRVGLRQVDPGNYVTP GDTNGIVVITQLQPMSVIFTTSEDNLPQILKQVNAGRKLSVTAYNRNNTVPLETGSLATL DNQIDTSTGTVKLRANFDNKEGMLFPNQFVNTRLLVDVLRNATIVPTSAVLTGSIGQFVY VVKPDNTVTVRKVTIGPVDGERTSIVSGVMLGERVVTDGSDRLREGSKISIPADKPKGAS GAHGAGAASGASAASGAAS*(449)QAAAPAAQ |
Sequence Around Glycosites (21 AA) | SGASAASGAASQAAAPAAQ |
Technique(s) used for Glycosylation Detection | ZIC-HILIC,immunoblotting,tryptic digestion, and MS/MS analysis |
Technique(s) used for Glycosylated Residue(s) Detection | MS/MS analysis |
Glycan Information | |
Glycan Annotation | Trisaccharide HexNAc-HexNAc-Hex. |
BCSDB ID | 12058 |
GlyTouCan | G71937MV |
Protein Glycosylation linked (PGL) gene(s) | |
OST Gene Name | PglLBC |
OST ProGT ID | ProGT71 (PglLBc) |
Literature | |
Reference | Lithgow KV, Scott NE, Iwashkiw JA, Thomson EL, Foster LJ, Feldman MF, Dennis JJ. (2014) A general protein O-glycosylation system within the Burkholderia cepacia complex is involved in motility and virulence. Mol Microbiol., 92(1):116-37. [PubMed: 24673753] |
Author | Lithgow KV, Scott NE, Iwashkiw JA, Thomson EL, Foster LJ, Feldman MF, Dennis JJ. |
Research Group | Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada, |
Corresponding Author | Dennis JJ. |
Contact | Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada, |