ProGP473 (Peptidoglycan-binding membrane protein)

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ProGP ID ProGP473 (Peptidoglycan-binding membrane protein)
Validation Status Characterized
Organism Information
Organism NameBurkholderia cenocepacia K56-2
Domain Bacteria
Classification Family: Burkholderiaceae
Order: Burkholderiales
Class: Betaproteobacteria
Division or phylum: "Proteobacteria"
Taxonomic ID (NCBI) 985075
Genome Information
GenBank NZ_LAUA01000000
EMBL LAUA01000000
Organism Additional Information Burkholderia cenocepacia causes opportunistic infections in plants, insects, animals and humans. It acts as a health threat to cystic fibrosis patients, causing lethal necrotizing pneumonia in some cases.
Gene Information
Gene Namebcen2306
GenBank Gene Sequence NC_011000.1.
Protein Information
Protein NamePeptidoglycan-binding membrane protein
UniProtKB/SwissProt ID A0A0H2XSY8
NCBI RefSeq WP_011546328.1
EMBL-CDSABF77207.1.
UniProtKB Sequence >tr|A0A0H2XSY8|A0A0H2XSY8_BURCA Sporulation related protein OS=Burkholderia cenocepacia (strain AU 1054) GN=Bcen_2306 PE=4 SV=1 MAQPRRTSKQSKQAGGTFLGIVLGLIVGLAIAVVVALYITRSPSPFVSKVAPPPADNGAS QPQQFDPNRALQGKTPGQPVPQAAQSAPPNTAPGQAANQTQGGLLPEPQIVEVPPSGNTN GATGSSNTTASNTPSSGNGVAVAPKPADTTPPPKKTQQAQQQQQGGEDDLARFAAQKQAQ QAAAQKQQQQQQAANTPKPTSSAAAAAAAAKPPTANDANTGYFLQVGAYKTEGDAEQQRA RLGFQGFESKVSKRDVSGVTYFRVRVGPFSKFEDMNSARQRLSDAGVDTAVIRFTKQ
Sequence length 297 AA
Subcellular LocationMembrane
Glycosylation Status
Glycosylation Type O- (Ser/Thr) linked
Experimentally Validated Glycosite(s) in Full Length ProteinS60
Glycosite(s) Annotated Protein Sequence >tr|A0A0H2XSY8|A0A0H2XSY8_BURCA Sporulation related protein OS=Burkholderia cenocepacia (strain AU 1054) GN=Bcen_2306 PE=4 SV=1 MAQPRRTSKQSKQAGGTFLGIVLGLIVGLAIAVVVALYITRSPSPFVSKVAPPPADNGAS*(60) QPQQFDPNRALQGKTPGQPVPQAAQSAPPNTAPGQAANQTQGGLLPEPQIVEVPPSGNTN GATGSSNTTASNTPSSGNGVAVAPKPADTTPPPKKTQQAQQQQQGGEDDLARFAAQKQAQ QAAAQKQQQQQQAANTPKPTSSAAAAAAAAKPPTANDANTGYFLQVGAYKTEGDAEQQRA RLGFQGFESKVSKRDVSGVTYFRVRVGPFSKFEDMNSARQRLSDAGVDTAVIRFTKQ
Sequence Around Glycosites (21 AA) VAPPPADNGASQPQQFDPNRA
Technique(s) used for Glycosylation DetectionZIC-HILIC,immunoblotting,tryptic digestion, and MS/MS analysis
Technique(s) used for Glycosylated Residue(s) Detection MS/MS analysis
Glycan Information
Glycan Annotation Trisaccharide HexNAc-HexNAc-Hex.
BCSDB ID 12058
GlyTouCan G71937MV
Protein Glycosylation linked (PGL) gene(s)
OST Gene NamePglLBC
OST ProGT IDProGT71 (PglLBc)
Literature
ReferenceLithgow, K.V., Scott, N.E., Iwashkiw, J.A., Thomson, E.L., Foster, L.J., Feldman, M.F. and Dennis, J.J., 2014. A general protein O‐glycosylation system within the B urkholderia cepacia complex is involved in motility and virulence. Molecular microbiology, 92(1), pp.116-137.
Corresponding Author Jonathan J. Dennis
ContactDepartment of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada,
ReferenceLithgow KV, Scott NE, Iwashkiw JA, Thomson EL, Foster LJ, Feldman MF, Dennis JJ. (2014) A general protein O-glycosylation system within the Burkholderia cepacia complex is involved in motility and virulence. Mol Microbiol., 92(1):116-37. [PubMed: 24673753]
AuthorLithgow KV, Scott NE, Iwashkiw JA, Thomson EL, Foster LJ, Feldman MF, Dennis JJ.
Research GroupDepartment of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada
Corresponding Author Dennis JJ.
ContactDepartment of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada,