S. aureus is a human pathogen responsible for life-threatening infections as it is able to attach to surfaces, form biofilms, and persist inside the host. It causes mild skin
infections and even serious and life-threatening infections, such as endocarditis, osteomyelitis, pneumonia, meningitis, and sepsis.
Pls is a virulence factor that reduces the adherence of S. aureus to Fg, Fn, or endothelial cells, internalization by human host cells and phagocytosis by polymorphonuclear neutrophils (PMNs) independently of its glycosylation status.
Bleiziffer I, Eikmeier J, Pohlentz G, McAulay K, Xia G, Hussain M, Peschel A, Foster S, Peters G, Heilmann C.
Research Group
1 Institute of Medical Microbiology, University of Münster, Münster, Germany.
2 Interdisciplinary Center for Clinical Research (IZKF), University of Münster, Münster, Germany.
3 Institute for Hygiene, University of Münster, Münster, Germany.
4 Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom.
5 Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
6 Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany.
7 German Center for Infection Research (DZIF), partner site Tübingen, University of Tübingen, Tübingen, Germany.
8 Cluster of Excellence EXC 1003, Cells in Motion, University of Münster, Münster, Germany
Corresponding Author
Heilmann C
Contact
1 Institute of Medical Microbiology, University of Münster, Münster, Germany.
2 Interdisciplinary Center for Clinical Research (IZKF), University of Münster, Münster, Germany.