ProGP692 (SpaCBA)
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| ProGP ID | ProGP692 (SpaCBA) |
| Validation Status | Uncharacterized |
| Organism Information | |
| Organism Name | Lactobacillus rhamnosus GG |
| Domain | Bacteria |
| Classification | Phylum : Firmicutes Class : Bacilli Orders : Lactobacillales Family : Lactobacillaceae Genus : Lactobacillus Species : rhamnosus Strain : GG |
| Taxonomic ID (NCBI) | 568703 |
| Protein Information | |
| Protein Name | SpaCBA |
| Subcellular Location | pili |
| Function | SpaCBA pili of the model probiotic and beneficial human gut microbiota isolate Lactobacillus rhamnosus GG |
| Glycosylation Status | |
| Glycosylation Type | O- (Ser/Thr) linked |
| Technique(s) used for Glycosylation Detection | Lectin blotting |
| Protein Glycosylation- Implication | These glycans on the pili are recognized by human dendritic cells via the C-type lectin receptor DC-SIGN, a key carbohydrate-dependent immune tailoring pattern recognition receptor. |
| Glycan Information | |
| Glycan Annotation | mannose and fucose |
| Literature | |
| Year of Identification | 2016 |
| Reference | Tytgat, H.L., van Teijlingen, N.H., Sullan, R.M.A., Douillard, F.P., Rasinkangas, P., Messing, M., Reunanen, J., Satokari, R., Vanderleyden, J., Dufrêne, Y.F. and Geijtenbeek, T.B., 2016. Probiotic gut microbiota isolate interacts with dendritic cells via glycosylated heterotrimeric pili. PLoS One, 11(3), p.e0151824. |
| Corresponding Author | Sarah Lebeer |
| Contact | Centre of Microbial and Plant Genetics, K,U,Leuven, Kasteelpark Arenberg 20, box 2460, B-3001 Leuven, Belgium |