ProGP708 (WTA-wall teichoic acid)
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| ProGP ID | ProGP708 (WTA-wall teichoic acid) |
| Validation Status | Characterized |
| Organism Information | |
| Organism Name | Staphylococcus aureus |
| Domain | Bacteria |
| Classification | Phylum : Firmicutes Class : Bacilli Orders : Bacillales Family : Staphylococcaeae Genus : Staphylococcus Species : aureus |
| Taxonomic ID (NCBI) | 1280 |
| Genome Information | |
| Organism Additional Information | It causes often fatal infections in humans which are difficult to treat. |
| Protein Information | |
| Protein Name | cell wall |
| Subcellular Location | cell wall |
| Function | Beta-lactam resistance, host invasiveness and virulence |
| Glycosylation Status | |
| Glycosylation Type | C-linked |
| Experimentally Validated Glycosite(s) in Full Length Protein | C3, C4 |
| Technique(s) used for Glycosylation Detection | NMR spectrosocopy |
| Glycan Information | |
| Glycan Annotation | Monosaccharide (GlcNac) |
| Technique(s) used for Glycan Identification | NMR spectroscopy |
| Literature | |
| Year of Identification | 2018 |
| Reference | Gerlach, D., Guo, Y., De Castro, C., Kim, S.H., Schlatterer, K., Xu, F.F., Pereira, C., Seeberger, P.H., Ali, S., Codée, J. and Sirisarn, W., 2018. Methicillin-resistant Staphylococcus aureus alters cell wall glycosylation to evade immunity. Nature, 563(7733), pp.705-709. |
| Corresponding Author | Thilo Stehle Andreas Peschel |
| Contact | Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany. German Centre for Infection Research (DZIF), Partner Site Tübingen, Tübingen, Germany |
| Reference | Brown, S., Xia, G., Luhachack, L.G., Campbell, J., Meredith, T.C., Chen, C., Winstel, V., Gekeler, C., Irazoqui, J.E., Peschel, A. and Walker, S., 2012. Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids. Proceedings of the national academy of sciences, 109(46), pp.18909-18914. |
| Corresponding Author | Suzanne Walker Guoqing Xia |
| Contact | Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115 Cellular and Molecular Microbiology Section, InterfacultyInstitute of Microbiology and Infection Medicine, University of Tübingen, Elfriede-Aulhorn-Strasse 6, D-72076 Tübingen, Germany |
| Reference | Winstel, V., Kühner, P., Salomon, F., Larsen, J., Skov, R., Hoffmann, W., Peschel, A. and Weidenmaier, C., 2015. Wall teichoic acid glycosylation governs Staphylococcus aureus nasal colonization. MBio, 6(4), pp.e00632-15. |
| Corresponding Author | Andreas Peschel |
| Contact | 1. Cellular and Molecular Microbiology Division, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany 2. German Center for Infection Research (DZIF), Partner Site Tübingen, Tübingen, Germany. |
| Reference | Missiakas, D., 2019. Staphylococcus aureus TarP: A brick in the wall or rosetta stone?. Cell host & microbe, 25(2), pp.182-183. |
| Corresponding Author | Dominique Missiakas |
| Contact | Department of Microbiology, The University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA |