ProGT101 (TtOGT)
| ProGT ID | ProGT101 (TtOGT) |
| Organism Information | |
| Organism Name | Thermobaculum terrenum (strain ATCC BAA-798 / YNP1) |
| Domain | Bacteria |
| Phylum | Cyanobacteria |
| Classification | Family: Thermomicrobiaceae Order: Sphaerobacterales Phylum: Cyanobacteria |
| Taxonomic ID (NCBI) | 525904 |
| Genome Information | |
| Gene Bank | CP001826 |
| EMBL | CP001826 |
| Gene Information | |
| Gene Name | Tter_2822 |
| NCBI Reference Sequence | ACZ43705 |
| Protein information | |
| Protein Name | TtOGT |
| UniProtKB/ SwissProt ID | D1CIY5 |
| NCBI Ref Seq | WP_012876736.1 |
| UniProtKB Sequence | >tr|D1CIY5|D1CIY5_THET1 Tetratricopeptide TPR_2 repeat protein OS=Thermobaculum terrenum (strain ATCC BAA-798 / YNP1) GN=Tter_2822 PE=1 SV=1 MTTRDAATIKALLSHAHEAQRSGDVLASERACWRVLQIAPDNSEALHLLGLLHGECGNYG LAATLLRRAVALDPGEASYHYNLGNVLVASGQVERGITSLHHALELRPDYHRAHSGLYVA LHYSALYDPRARHILALDWARRYADPLTPVPATPVDPDPHRRLRIGYVSGELRCHPVGYF LEPVIEAHDRTAYEVYCYSNDPRSDALTDRLRALSDRWRDVWPLTDAELCELVRRDGIDI LVDLSWHLGMHRLFAFARRPAPVQVTWLAAINTTGMRAMDYLVGDQHLCPPGSDELYTER LVRLSRFYLPCNPPPDLPGWAPADPLGRGFPVFGCFNRLSKIGPEVLDLWAKILLALPRA RLRLIATGLQDPVTSSRLMRALEGRGVAGERLELLSPMPRTDLLATYNDIDVALDTLPYS GCTTSLEALWMGVPVVTLEGADMAGRATSSLLRWAGLQELVSRTQEEYIDIALGLGRDLG TLARLREHLRRWLRSVSMSDQGSFTAELEDAYRRMWRDACQTAAGRQGA |
| EMBL CDS | ACZ43705.1 |
| Sequence length | 529 AA |
| Subcellular Location | Cytoplasmic |
| String | 525904.Tter_2822 |
| Additional Information | 1) When bacterial cells were treated with the OGT inhibitor UDP-5S-GlcNAc, the complete inhibition of T. terrenum growth observed this suggest that OGT is essential for the survival of T. terrenum. |
| PDB ID | 5DJS |
| Glycosyltransferase Information | |
| Glycosylation Type | O- (Ser/Thr) linked |
| CAZY Family | GT41 |
| EC Number (BRENDA) | 2.4.1.- |
| Mechanism of Glycan Transfer | Sequential |
| Donor Type | Nucleotide activated sugars |
| Donor Specificity | UDP-GlcNAc |
| Glycan Information | |
| Glycan transferred | Monosaccharide (GlcNAc) |
| Experimental_strategies | In vivo and In vitro |
| Litrature | |
| Year Of Validation | 2015 |
| Reference | Ostrowski, A., Gundogdu, M., Ferenbach, A. T., Lebedev, A. A., & van Aalten, D. M. (2015). Evidence for a functional O-GlcNAc system in the thermophilic bacterium Thermobaculum terrenum. Journal of Biological Chemistry, jbc-M115. |
| Authors | Ostrowski, A., Gundogdu, M., Ferenbach, A. T., Lebedev, A. A., & van Aalten, D. M. |
| Research groups | The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA |
| Corresponding Author | van Aalten, D. M. |
| Contacts | The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA |