ProGT107 (PAV_2c01630)

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ProGT ID ProGT107 (PAV_2c01630)
Organism Information
Organism NamePaenibacillus alvei CCM 2051T
Clinical ImplicationPathogenic
DomainBacteria
Classification Phylum : Firmicutes
Class : Bacilli
Orders : Bacillales
Family : Paenibacillaceae
Genus : Paenibacillus
Species : alvei
Strain : CCM 2051T
Taxonomic ID (NCBI)1206781
Genome Information
Gene BankAMBZ01000002
EMBLAMBZ01000002
Gene Information
Gene NamePAV_2c01630
Protein information
UniProtKB/ SwissProt IDK4ZGL5
UniProtKB Sequence>tr|K4ZGL5|K4ZGL5_PAEA2 Glycosyl transferase family 2 OS=Paenibacillus alvei (strain ATCC 6344 / DSM 29 / NBRC 3343 / NCIMB 9371 / NCTC 6352) OX=1206781 GN=PAV_2c01630 PE=4 SV=1 MTRPKISLCMIVKNEESCLERCLDSVKNIVDEIVIVDTGSTDRTLQILEERGITAHHYNW NHHFGDARNHAISFATGEYILQLDADEYLDESTKGVLKEPLDCDCYILKIRNDLGSGFNE VHSSIRLFRNSPKIKYVGALHEHIDTETTKLKHGKLSVLIHHDGYQQSVIDKKNKNKRNM QIIKKEAKLNPDAFNLYNLGVQLKIEGEHLAAIDAFKKSFAAGSNYTFTPKLLVYLGQSL MELNRHEESLAVFRDSIALYPTYTDLHYFKGFVYEKIEYFRDAEACYKKCLEIGEVSETY HNSQEGVGSYLAHAQLAELYLKEERREESLNHALEALKGSKNSFPTLKVFLNIFPGGDRK QLYGILKQVWNLDSDKDLELLLIALYQIRHPLLLNYVEEYNVSIPYEMQRFLLLMDKKYE EVLEREAVNGELARDQSSQYGRDMLLLSFVTRDENLYNRASLDINLNQKESKILKR
Sequence length628 AA
Function in Native Organism 1) Essential for flagella production and bacterial motility.
Additional Information1) Deletion studies of PAV_2c01630 and PAV_2c01640 indicate that flagellin glycosylation in P. alvei is essential for the flagella formation and bacterial motility.
2) Purified Hag protein (PAV_2c01710) is modified with an O-linked trisaccharide composed of one hexose and two N-acetyl-hexosamine residues, at three sites of glycosylation.
Glycosyltransferase Information
Glycosylation TypeO- (Ser/Thr) linked 
EC Number (BRENDA)2.4.1.-
Mechanism of Glycan TransferSequential
Glycan Information
Method of Glycan IndentificationMALDI-TOF-MS peptide mass fingerprinting, and LC-ESI-IT-MS/MS
Experimental_strategiesIn vivo 
Acceptor Subtrate Information
Acceptor Substrate name Hag
ProGPdb ID ProGP520
Litrature
Year Of Validation2016 
Reference Janesch, B., Schirmeister, F., Maresch, D., Altmann, F., Messner, P., Kolarich, D. and Schäffer, C., 2016. Flagellin glycosylation in Paenibacillus alvei CCM 2051T. Glycobiology, 26(1), pp.74-87.

Corresponding AuthorDepartment of NanoBiotechnology, NanoGlycobiology Unit, University of Natural Resources and Applied Life Sciences, Vienna, Muthgasse 11, Vienna A-1190, Austria