ProGT79 (BAHTCr)
ProGT ID | ProGT79 (BAHTCr) |
Organism Information | |
Organism Name | Citrobacter rodentium (strain ICC168) (Citrobacter freundii biotype 4280) |
Clinical Implication | Pathogenic |
Domain | Bacteria |
Phylum | Proteobacteria |
Classification | Family: Enterobacteriaceae Order: Enterobacteriales Class: Gammaproteobacteria Division or phylum: "Proteobacteria" |
Taxonomic ID (NCBI) | 637910 |
Genome Information | |
Gene Bank | FN543503 |
EMBL | FN543503 |
Gene Information | |
Gene Name | ROD_p1111 |
NCBI Reference Sequence | FN543503 |
Protein information | |
Protein Name | BAHTCr |
UniProtKB/ SwissProt ID | D2TV87 |
NCBI Ref Seq | WP_012908907.1 |
UniProtKB Sequence | >tr|D2TV87|D2TV87_CITRI Putative adhesin glycosyltransferase OS=Citrobacter rodentium (strain ICC168) GN=ROD_p1111 PE=4 SV=1 MQKSLATFFISPPEIPTQHGPDNILYDFNDGARVLLPEGKWHVRLLDADSGNILFCCDIN NGWVTSSKKYFVRFRIQVFRQGEDSPLLDETLNLTDRDVLISFPTGTLGDLLGWFPYAER FQSLHQCRLECTMAQDIIDLLAPQYPQICFSTPEKPRTTEPYATYRVGLYFGGDTNNQPV DFRQVGFHRSAGYILGVDPREAPVRLNLSAPCTIREPYVCIATQSTCQAKYWNNGTGWSE VVAHLKSLGYRVLCIDREAHYGQGFVWNHIPWGAEDFTGSFPLQERVNLLRHASFFIGLA SGLSWLAWATGIPVVLISGFSLPDSEFYTPWRVFNSHGCNGCWDDTSLNFDHKDFLWCPR HKNTDRQFECTRLITGTQVNGVISRLHASLMKQGDKACLTKGTNNEQGL |
EMBL CDS | CBG91773.1 |
Sequence length | 409 AA |
Additional Information | 1) BAHTCr, heptosyltransferases able complement AAH (E. coli) in restoring AIDA-I glycosylation and bacterial adhesion to HeLa cells. 2) BAHTCr is involved in a transfer of heptose to CARC autotransporter which is very critical for C. rodentium colonization in mice colon. |
Glycosyltransferase Information | |
Glycosylation Type | O- (Ser/Thr) linked |
CAZY Family | GTNC |
EC Number (BRENDA) | 2.4.1.- |
Mechanism of Glycan Transfer | Sequential |
Donor Type | Nucleotide activated sugars |
Donor Specificity | ADP-Heptose |
Glycan Information | |
Glycan transferred | Monosaccharide (Heptose)Â |
Method of Glycan Indentification | ECL glycoprotein detection kit |
Experimental_strategies | In vivo and In vitro |
Acceptor Subtrate Information | |
Acceptor Substrate name | AIDA-I (CARC) |
ProGPdb ID | ProGP201 |
Acceptor Substrate name | TibA |
ProGPdb ID | ProGP176 |
Litrature | |
Year Of Validation | 2014Â |
Reference | Lu, Q., Yao, Q., Xu, Y., Li, L., Li, S., Liu, Y., Gao, W., Niu, M., Sharon, M., Ben-Nissan, G. & Zamyatina, A. (2014). An iron-containing dodecameric heptosyltransferase family modifies bacterial autotransporters in pathogenesis. Cell host & microbe, 16(3), 351-363. |
Authors | Lu, Q., Yao, Q., Xu, Y., Li, L., Li, S., Liu, Y., Gao, W., Niu, M., Sharon, M., Ben-Nissan, G. & Zamyatina, A. |
Research groups | 1 National Institute of Biological Sciences, Beijing 102206, China.National Institute of Biological Sciences, Beijing 102206, China. 2 College of Biological Sciences, China Agricultural University, Beijing 100094, China. 3 Institute of Analytical Chemistry & Synthetic and Functional Biomolecules Center. 4 College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China. 5 Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel. 6 Department of Chemistry, University of Natural Resources and Life Sciences, A-1190 Vienna, Austria. 7 National Institute of Biological Sciences, Beijing 102206, China. 8 National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. 9 National Institute of Biological Sciences, Beijing, Collaborative Innovation Center for Cancer Medicine, Beijing 102206, China. |
Corresponding Author | Zamyatina, A. |
Contacts | 1 National Institute of Biological Sciences, Beijing 102206, China. 2 National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, 3 China National Institute of Biological Sciences, Beijing, Collaborative Innovation Center for Cancer Medicine, Beijing 102206, China. |
Reference | Yao, Q., Lu, Q., Wan, X., Song, F., Xu, Y., Hu, M., ... & Shao, F. (2014). A structural mechanism for bacterial autotransporter glycosylation by a dodecameric heptosyltransferase family. Elife, 3, e03714. |
Authors | Yao, Q., Lu, Q., Wan, X., Song, F., Xu, Y., Hu, M., ... & Shao, F. |
Research groups | 1 Dr Feng Shaos Laboratory, National Institute of Biological Sciences, Beijing, China. 2 Dr Niu Huangs Laboratory, National Institute of Biological Sciences, Beijing, China. 3 National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. 4 Institute of Analytic Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, China. 5 Department of Chemistry, University of Natural Resources and Life Sciences, Vienna, Austria. |
Corresponding Author | Shao, F. |
Contacts | Dr Feng Shaos Laboratory, National Institute of Biological Sciences, Beijing, China |